Bioprocessors must minimize the aggregation of therapeutic proteins, but that’s not an easy task. Proteins can aggregate during any step from manufacturing to administering a drug. “The aggregation ...

Most neurodegenerative diseases, including dementias, involve proteins aggregating into filaments called amyloids. In most of these diseases, researchers have identified the proteins that aggregate, ...

Researchers present a special silicon nitride nanopore-based sensing device that is designed to provide volume information about tau and tubulin protein molecules and their aggregation states. To ...

Proteins misfolding and clumping together, a process known as aggregation, is a key feature seen in several neurological conditions, including Alzheimer's and Parkinson's diseases. These disorders ...

Liquid-liquid phase separation is not a precursor to formation of amyloid fibrils, a pathological hallmark of Parkinson’s disease, shows study. Rather, the formation of protein into liquid droplets ...

The aging brains of people with Alzheimer’s, Parkinson’s and other neurodegenerative diseases are suffused with telltale aggregates of proteins in or around their neurons. How these protein clumps ...

Several neurodegenerative diseases begin when toxic protein clumps form in neurons. Scientists have yet to find a good way to clear these clumps from cells. Researchers now report that a ...

In a recent study published in the journal Nature, a group of researchers investigated how aging alters neuronal protein degradation, aggregation, and transfer to microglia, with a focus on synaptic ...

Barcelona researchers have created an algorithm for studying protein aggregation and mutating proteins from AlphaFold.