Septicshock was described as hypotension and organ dysfunction that persisted despite volume resuscitation, necessitating vasoactive medication, and with 2 or more of the SIRS criteria listed above.
While the new Surviving Sepsis Guidelines no longer include SIRS criteria, the SOFA and qSOFA were developed as tools to predict outcomes and not for diagnostic purposes.
According to the first modern definition, in 1992, sepsis was described as an overabundant inflammatory response to infection, recognized by the presence of the systemic inflammatory response...
Sepsis is a clinical syndrome characterized by a dysregulated host response to infection. There is a continuum of severity ranging from sepsistosepticshock. Although wide-ranging and dependent upon the population studied, mortality has been estimated to be ≥10 percent and ≥40 percent when shock is present [1,2].
Sepsis and Septic Shock - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.